I am a neurobiologist by training, with specific interest in the cellular mechanisms
of neurodegeneration. My Ph.D. project focused on the pathogenesis of Huntington’s
disease and the involvement of the tumor suppressor protein, p53, in disease progression.
During my postdoctoral training, I studied the role of DNA damage in Alzheimer’s disease
and in normal brain aging. I am currently researching the deleterious effects of Huntington’s
disease in peripheral tissues, such as the pancreas.
Stevenson, M., Carlisle, R., Davies, B., Preece, C., Hammett, M., Liu, W., Owen, D.,
Adesina, A., Fisher, K., Gluba, W., Ryan, A. B., Cronin, C., Scrable, H., & Seymour, L. (2013). Development of a positive-readout
mouse model of siRNA pharmacodynamics. Molecular Therapy — Nucleic Acids, 2, e133.
Ryan, A. B. & Scrable, H. (2008) Mutant alleles of HD improve the life span of p53-/- mice. Mechanisms of Ageing and Development, 4, 238–241.
Ryan, A. B., Zeitlin, S., & Scrable, H. (2006) Genetic interaction between expanded Hdh alleles
and p53 in the mouse reveal the deleterious effects of p53 on Huntington’s Disease
pathogenesis. Neurobiology of Disease, 24
Ryan, A. B., & Scrable, H. (2004) Visualization of the dynamics of gene expression in the living
mouse. Molecular Imaging, 3, 33–41.
Cronin, C. A., Ryan, A. B., Talley, E. M., & Scrable, H. (2003) Tyrosinase expression during neuroblast divisions
affects later pathfinding by retinal ganglion cells. Journal of Neuroscience. 23, 1692–11697.
